Clinical Laboratory Medicine




Clinical Laboratory Medicine


McClatchey, Kenneth D., MD, DDS; Alkan, Serhan, MD; Hackel, Emanuel, PhD; Keren, David F., MD; Lee-Lewandrowski, Elizabeth , PhD, MPH; Lewandrowski, Kent B., MD

Price: $149.00               Format: Hardcover, 2nd ed.
ISBN: 0683307517                   Publisher: Lippincott Williams & Wilkins
Pub. Date: November  2001

New edition of a text that offers the latest information on clinical laboratory medicine. Each of the 75 contributions consists of an introduction, followed by a discussion of disease status (including pathophysiology), diagnostic methods, and interpretation (including sensitivity, specificity, precision, and accuracy issues, where applicable). In addition to general laboratory information, it includes many new technologies such as molecular pathology, cytogenetics, HLA, molecular biology, as well as discussion of quality management, cost accounting, and informatics. Illustrated with color and B&W images. Edited by McClatchey (Loyla U. Medical Center).

 From the Critics
This is a nice update from the previous edition. Of the 11 major sections, two (one on molecular pathology and one on HLA: the major histocompatibility complex) are relatively new to textbooks of laboratory medicine. The remaining nine sections are devoted to the traditional disciplines of laboratory medicine and are nicely updated. There are color photomicrographs and didactic illustrations liberally sprinkled throughout and nicely complementing the text, and the cover illustrations entice one to read further. (Given this excellent use of color, I must admit, however, that I was disappointed that the chapteron lymphomas contained only black-and-white photomicrographs.) The book is remarkably thorough and complete. The only shortcoming of this approximately 1,700 page book is its weight:I have to use both arms to lift it!

 Table of Contents
Sect. I General Laboratory 1


Basic Laboratory Management 3


Business Management of the Clinical Laboratory 49


Laboratory Safety 78


The Interpretation of Laboratory Tests 97


Laboratory Information Systems 122


Ethics in Laboratory Medicine 134
Sect. II Molecular Pathology 143


Introduction to Molecular Diagnostics 145


Molecular Biology of Inherited Diseases 163


Molecular Biology of Solid Tumors 175


Molecular Biology of Infectious Diseases 186


Clinical Applications of Molecular Biology Hematopoietic Disorders 211
Sect. III Clinical Chemistry 239


Immunochemical Methods 241


The Plasma Proteins 263


Diagnostic Enzymology and Other Biochemical Markers of Organ Damage 281


Lipids and Lipoproteins 306


Endocrine Function and Carbohydrates 322


Electrolytes and Acid-Base Balance 347


Respiration and Measurement of Oxygen and Hemoglobin 366


Nitrogen Metabolites and Renal Function 378


Calcium, Magnesium, and Phosphate 392


Heme Synthesis and Catabolism 407


Toxicology 418


Trace Elements, Vitamins, and Nutrition 439


Inborn Metabolic Errors 463


Point-of-Care Testing 483


Tumor Markers 489
Sect. IV Medical Microscopy and Urinalysis 499


Synovial, Pleural, and Peritoneal Fluids 501


Urine 519
Sect. V Cytogenetics 553


Basic Cytogenetics 555


Clinical Cytogenetics 589


Prenatal Cytogenetic Diagnosis 636


Cytogenetic Studies in Neoplastic Hematologic Disorders 658


The Chromosome-Breakage Syndromes: Clinical Features, Cytogenetics, and Molecular Genetics 686


Solid Tumor Cytogenetics 704
Sect. VI HLA: The Major Histocompatibility Complex 731


HLA: Structure, Function, and Methodologies 733


Molecular HLA Typing 754


HLA: Applications 763


Bone Marrow Transplantation 779
Sect. VII Hematology 787


Hematopoiesis and the Hematopoietic Growth Factors 789


Peripheral Blood and Bone Marrow: Morphology, Counts and Differentials, and Reactive Disorders 797


Red Blood Cell Disorders 830


The Thalassemia and Hemoglobinopathy Syndromes 866


Acute Leukemias and Myelodysplastic Syndromes 896


Chronic Lymphoproliferative Disorders, Immunoproliferative Disorders, and Malignant Lymphoma 923


Chronic Myeloproliferative Disorders 964
Sect. VIII Coagulation 985


Overview of Hemostasis 987


Laboratory Evaluation of Platelet Disorders 1010


Coagulation Abnormalities 1033


Thrombophila 1050
Sect. IX Microbiology 1057


Specimen Collection and Processing for Microbiology 1059


Bacteriology 1074


Fungi and Fungal Infections 1125


Chlamydia, Mycoplasma, and Rickettsia 1157


Aerobic Actinomycetes 1201


Antimicrobial Susceptibility Testing 1221


Molecular Techniques for Diagnosis of Infectious Diseases 1236


Role of the Clinical Microbiology Laboratory in Hospital Epidemiology and Infection Control 1247


Autopsy Microbiology 1256


Diagnostic Virology 1266


Parasitology 1291
Sect. X Immunopathology 1345


Basic Principles of Immunodiagnosis 1347


Flow Cytometry 1401


Cellular and Humoral Mediators of Inflammation 1426


Monoclonal Gammopathies 1448


Primary Immunodeficiency Diseases 1458


Allergic Conditions 1471


Receptor Assays of the Clinical Laboratory 1486
Sect. XI Blood Bank/Transfusion Medicine 1515


Organization, Functions, Regulation, and Legal Concerns of Blood Banks 1517


Blood Collection 1522


Pretransfusion Testing 1533


Blood Component Therapy 1545


Transfusion Therapy 1567


Neonatal Transfusion 1602


Complications of Blood Transfusion 1616


Immune Hemolysis 1633
Subject Index 1647



Kenneth Donald McClatchey, DDS, MDKeneth-McClatchey.jpg

  Kenneth D. McClatchey, DDS, MD, editor of the Archives of Pathology & Laboratory Medicine, died December 21, 2003, at the University of Michigan Hospital, Ann Arbor, from kidney failure as a complication of pancreatic cancer. He was 61 years old.

Dr McClatchey was called a ¡°Renaissance Pathologist¡± because of his broad range of expertise in anatomic and clinical pathology, combined with a passion for teaching, research, and laboratory innovations. He was born in Detroit, Mich, grew up on an island in the Detroit River, and went to high school in Wyandotte, Mich. After graduating in 1960, he entered the University of Michigan's undergraduate school in Ann Arbor and obtained a BS degree in 1964. He continued at the University of Michigan in the School of Dentistry, graduating with a DDS degree in 1968, followed by his admission to the Rackham School of Graduate Studies at the University of Michigan where he obtained a Master's Degree in Oral Pathology in 1971.

The University of California San Francisco was Dr McClatchey's next destination, where he worked for a year in dentistry and oral pathology. Encouraged by his mentors, he applied to medical school at his alma mater, the University of Michigan at Ann Arbor, and was admitted in 1972. He completed medical school in 1975 and continued there in a pathology residency program, which he finished in 1978. He joined the faculty at Michigan immediately after his residency as assistant professor in the Departments of Pathology in the Medical School and Oral Pathology in the School of Dentistry.

His boundless intellectual capacity paved the way for a meteoric rise up the academic ranks. In rapid succession he became associate professor of pathology, associate director of clinical laboratories, and was named associate chairman of the Department of Pathology in 1982. He later served as vice chair of the department and director of the clinical laboratories. Dr McClatchey was made a full professor of pathology in 1988. He retired as professor emeritus from the Medical and Dental Schools at the University of Michigan in 1996 when he was hired as chairman of the Pathology Department at Loyola University Medical Center, Maywood, Ill. Dr McClatchey also was named the Helen M. and Raymond M. Galvin Professor. He served as chairman until 2002 and remained a professor in the Department of Pathology until his death.

His talent and drive allowed him to accomplish a feat few people have, namely becoming simultaneously an internationally recognized anatomic pathologist with expertise in head and neck pathology and a renowned clinical pathologist with an impressive track record in microbiology. Dr McClatchey had a marked inclination for research, receiving numerous grants in surgical pathology and microbiology during his career. He coupled this inclination with a natural writing ability, becoming a reviewer and editorial board member of numerous scientific journals. He was named editor of the ARCHIVES in 1998. He edited 2 editions of Clinical Laboratory Medicine, a leading textbook of clinical pathology, and also wrote extensively on pathology of the head and neck, as well as more than 150 articles on various subjects that appeared in prominent scientific journals.

Dr McClatchey had a passion for teaching. Generations of physicians and dentists at Michigan and Loyola were the recipients of his knowledge and experience, which were delivered with the ineffable sense of humor that endeared him to everyone with whom he came into contact. In his position as director of resident education at both Michigan and Loyola, he served as a role model and mentor to countless young pathologists. The creation of the Residents' Page section of the ARCHIVES was a concrete example of Dr McClatchey's commitment to encouraging and giving recognition to residents. In turn he was rewarded by his disciples with numerous honors and awards. He treasured most the awards he received as outstanding teacher at Michigan, and teacher of the year at Loyola in 2002.

All of these activities attracted the attention of various professional societies, which eagerly sought his association and his leadership. He was a member of the NCCLS, American Academy of Oral Pathology, American Association of Clinical Chemistry, American Society for Microbiology, American Society of Clinical Pathologists, American Association of Blood Banks, American Tissue Culture Association, Arthur Purdy Stout Society, US-Canadian Academy of Pathology, and the International Academy of Pathology. He most recently served as president of the World Association of Societies of Pathology and Laboratory Medicine.

Dr McClatchey contributed extensively to the College of American Pathologists (CAP). For nearly 30 years he volunteered his services to the CAP, becoming a member of committees too numerous to detail. He also served as a CAP governor from 1986 to 1992. During his career, he also was a consultant to the Veterans Administration, laboratories in Canada, the Pan American Health Organization, and the Canadian Standards Association. Since 2000, his most challenging consulting activity was with the International Atomic Energy Commission Project developing model laboratories in 12 Southeastern Asian countries in need.

These whirlwind lifelong activities were made possible by the love and support of Dr McClatchey's wife, Martha (Marty). She was his constant companion throughout his career, accompanying him on his travels through the United States and abroad. Family was a priority for Dr McClatchey, and together with Marty, they adopted and raised 4 children, Sean, Suki, Suni, and Stephen.

A memorial celebration of his life was held in the Ford Auditorium of the University of Michigan Medical Center on January 17, 2004. A capacity crowd attended and listened with rapt attention as colleagues, friends, and family described his various professional accomplishments and moments from his personal life. The love and respect he inspired was eloquently expressed by all the speakers. The memorial closed with a video showing Dr McClatchey throughout his life, his travels in this country and abroad, and his devotion to his wife and family.

Dr McClatchey made a difference on this earth, both to humanity at large and to pathology in particular. We will always be grateful to him.