blood coagulation cascade

The coagulation cascade is divided into      an intrinsic and an extrinsic pathway.

Coagulation factors : blue

Arrows () : proteolytic conversion Cofactors : red

Coagulation inhibitors : green

Fibrinolytic Proteins : brown

 abbreviations

F

factor

HK

high molecular weight kininogen

PAI-1

plasminogen activator inhibitor

PK

plasma kallikrein

TAFI

 

thrombin activatable fibrinolysis inhibitor

TFPI

tissue factor pathway inhibitor

tPA

tissue plasminogen activator

uPA

urokinase-type plasminogen activator. .

Strong and weak interactions are indicated by solid and dotted lines

[Reference] Tapper H, Herward H. Modulation of hemostatic mechanisms in bacterial infectious diseases. Blood. 2000;96(7):2329-2337

 

[2002.3.13]