WHO Classification of Hematopoietic & Lymphoid Neoplasmas

NOTE: Only major disease categories are listed.
{} indicates an alternative description of the neoplasm

 

MYELOID NEOPLASMS

 

  Myeloproliferative diseases
 

    Chronic myelogenous leukemia, Philadelphia chromosome positive  

        {t(9;22)(q34;q11)}, {BCR/ABL}

      Chronic neutrophilic leukemia
      Chronic eosinophilic leukemia/hypereosinophilic syndrome
      Chronic idiopathic myelofibrosis
      Polycythemia vera
      Essential thrombocythemia
 

    Myeloproliferative disease, unclassifiable

 

  Myelodysplastic/myeloproliferative diseases
      Chronic myelomonocytic leukemia
      Atypical chronic myelogenous leukemia
 

    Juvenile myelomonocytic leukemia

 

  Myelodysplastic syndromes
      Refractory anemia
      With ringed sideroblasts
      Without ringed sideroblasts
      Refractory cytopenia with multilineaage dysplasia
      Refractory anemia with excess blasts
      5q- (5q deletion) syndrome
 

    Myelodysplastic syndrome, unclassifiable

 

  Acute myeloid leukemias (AMLs)
      AMLs with recurrent cytogenetic translacations
          AML with {t(8;21)(q22;q22)}, {AML1(CBF-alpha)/ETO}
 

        Acute promyelocytic leukemia

           {AML with t(15;17)(q22;q11-12} and variants, {PML/RAR-alpha}

 

        AML with abnormal bone marrow eosinophils

            {inv(16)(p13q22)} or {t(16;16)(p13;q11)}, {CBFb/MYH11}

          AML with 11q23 abnormalities {MLL}
      AML with multilineage dysplasia
          With prior myelodysplasic syndrome
          Without prior myelodysplastic syndrome
      AML and myelodysplastic syndromes, therapy-related
          Alkylating agent-related
          Epipodophyllotoxin-related (some may be lymphoid)
 

        Other types

 

      AML not otherwise categoriezed
          AML minimally differentiated
          AML without maturation
          AML with maturation
          Acute myelomonocytic leukemia
          Acute monocytic leukemia
          Acute erythroid leukemia
          Acute megakaryocytic leukemia
          Acute basophilic leukemia
 

        Acute panmyelosis with myelofibrosis

 

  Acute biphenotypic leukemias
 

LYMPHOID NEOPLASMS

 

 

B-CELL NEOPLASMS

 

  Precursor B-cell neoplasm
      Precursor B-lymphoblastic leukemia/lymphoma
 

    Precursor B-cell acute lymphoblastic leukemia

 

  Mature (peripheral) B-cell neoplasms
  B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma
      B-cell prolymphocytic leukemia
      Lymphoplasmacytic lymphoma
      Splenic marginal zone B-cell lymphoma (with/without villous     lymphocytes)
      Hairy cell leukemia
  Plasma cell myeloma/plasmacytoma
      Extranodal marginal zone B-cell lymphoma of MAL type
      Nodal marginal zone B-cell lymphoma (with/without monocytoid     Bcells)
  Follicular lymphoma
      Mantle-cell lymphoma
      Diffuse large B-cell lymphoma
          Mediastinal large B-cell lymphoma
          Primary effusion lymphoma
  Burkitt lymphoma/Burkitt cell leukemia

 

 

T-CELL AND NK-CELL NEOPLASM

 

  Precursor T-cell neoplasm
      Precursor T-lymphoblastic lymphoma/leukemia
 

    Precursor T-cell acute lymphoblastic leukemia

 

  Mature (peripheral) T-cell neoplasms
      T-cell prolymphocytic leukemia
      T-cell granular lymphocytic leukemia
      Aggressive NK-cell leukemia
      Adult T-cell lymphoma/leukemia (HTLV-1 positive)
      Extranodal NK/T-cell lymphoma, nasal type
      Enteropathy-type T-cell lymphoma
      Hepatosplenic gamma-delta T-cell lymphoma
      Subcutaneous panniculities-like T-cell lymphoma
      Mycosis fungoides/Sezarysyndrome
      Anaplastic large-cell lymphoma, T/null cell, primary cutaneous     type
      Peripheral T-cell lymphoma, not otherwise characterized
      Angioimmunoblastic T-cell lymphoma
      Anaplastic large-cell lymphoma, T/null cell, primary systemic type
 


HODGKIN LYMPHOMA (HODGKIN DISEASE)

 

      Nodular lymphocyte-predominant Hodgkin lymphoma
      Classical Hodgkin lymphoma
      Nodular sclerosis Hodgkin lymphoma (grades 1 and 2)
          Lymphocyte-rich classical Hodgkin lymphoma
          Mixed cellularity Hodgkin lymphoma
          Lymphocyte depletion Hodgkin lymphoma

 

MAST CELL DISEASES

 

  Cutaneous mastocytosis
  Systemic mast cell disease
  Mast cell lekemia/sarcoma
   
 

HISTIOCYTIC AND DENDRITIC CELL NEOPLASMS

 

  Macrophage/histiocytic sarcoma
 

    Histiocytic sarcoma

 

  Dendritic cell neoplasms
      Langerhans cell histiocytosis
      Langerhans cell sarcoma
      Follicular dendritic cell sarcoma/tumor
      Dendritic cell sarcoma, not otherwise specified